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Thus, many scientists proposed that ALD patients be treated with integrated care by preventing AUD [357] and obtaining nutritional support [358,359,360,361]

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Additionally, the modulation of cystine-glutamate exchange via the system x c has been suggested as a new strategy to diminish the excitatory glutamatergic transmission observed after drugs of abuse, while drugs that influence that systemsuch as N-acetylcysteine (NAC)were considered as promising targets for the development of novel pharmacotherapies of SUD

Due to high toxicity of the compound the genetic end points were not noted for strain D7

The pre- and post-treatment subscores in five different domains are outlined in Table 4

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